Assay Detail
Binding
CHEMBL5159178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged Trypanosoma brucei HGXPRT expressed in Escherichia coli BL21 (DE3) cells using PRib-PP as substrate by spectrophotometric assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.47 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5208021 | — | — | 1 | 7.70 |
| CHEMBL5185227 | — | — | 1 | 7.70 |
| CHEMBL5171024 | — | — | 1 | 7.52 |
| CHEMBL5179417 | — | — | 1 | 7.52 |
| CHEMBL5187896 | — | — | 1 | 7.40 |
| CHEMBL5180101 | — | — | 1 | 7.22 |
| CHEMBL5204284 | — | — | 1 | 7.00 |
| CHEMBL5197487 | — | — | 1 | 7.00 |
| CHEMBL5194527 | — | — | 1 | 6.70 |
| CHEMBL5180136 | — | — | 1 | 6.60 |
| CHEMBL5180341 | — | — | 1 | 6.35 |
| CHEMBL5186759 | — | — | 1 | 6.22 |
| CHEMBL5205733 | — | — | 1 | 5.70 |
| CHEMBL5170511 | — | — | 1 | 5.70 |
| CHEMBL5185264 | — | — | 1 | 5.22 |
| CHEMBL5201462 | — | — | 1 | 5.05 |
| CHEMBL5193549 | — | — | 1 | 4.92 |
| CHEMBL5176444 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5208021 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL5185227 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL5171024 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL5179417 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL5187896 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL5180101 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL5204284 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL5197487 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL5194527 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL5180136 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL5180341 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL5186759 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL5205733 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL5170511 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL5185264 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL5201462 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL5193549 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL5176444 | — | Ki | = | 14000.0 | nM | 4.85 |