Assay Detail
Binding
CHEMBL5159488
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Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against <i>Trypanosoma cruzi</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 9.32 | 10.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4596414 | — | — | 1 | 10.09 |
| CHEMBL4594870 | — | — | 1 | 10.07 |
| CHEMBL4596647 | — | — | 1 | 10.05 |
| CHEMBL3558756 | — | — | 1 | 9.96 |
| CHEMBL5184737 | — | — | 1 | 9.96 |
| CHEMBL5171874 | — | — | 1 | 9.92 |
| CHEMBL5175270 | — | — | 1 | 9.89 |
| CHEMBL4594757 | — | — | 1 | 9.72 |
| CHEMBL5199542 | — | — | 1 | 9.59 |
| CHEMBL5176188 | — | — | 1 | 9.55 |
| CHEMBL4596941 | — | — | 1 | 9.47 |
| CHEMBL5183942 | — | — | 1 | 9.40 |
| CHEMBL4595806 | — | — | 1 | 9.31 |
| CHEMBL5191563 | — | — | 1 | 9.17 |
| CHEMBL5204190 | — | — | 1 | 9.16 |
| CHEMBL4597308 | — | — | 1 | 9.15 |
| CHEMBL4596992 | — | — | 1 | 9.13 |
| CHEMBL5179302 | — | — | 1 | 9.10 |
| CHEMBL4595664 | — | — | 1 | 9.07 |
| CHEMBL4598338 | — | — | 1 | 8.94 |
| CHEMBL541700 | GALLINAMIDE A | — | 1 | 8.89 |
| CHEMBL4595223 | — | — | 1 | 8.87 |
| CHEMBL5202965 | — | — | 1 | 8.81 |
| CHEMBL4595559 | — | — | 1 | 8.30 |
| CHEMBL5199098 | — | — | 1 | 7.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4596414 | — | IC50 | = | 0.081 | nM | 10.09 |
| CHEMBL4594870 | — | IC50 | = | 0.086 | nM | 10.07 |
| CHEMBL4596647 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL3558756 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL5184737 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL5171874 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL5175270 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL4594757 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL5199542 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL5176188 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL4596941 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL5183942 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4595806 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL5191563 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL5204190 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL4597308 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL4596992 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL5179302 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL4595664 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL4598338 | — | IC50 | = | 1.14 | nM | 8.94 |
| CHEMBL541700 | GALLINAMIDE A | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4595223 | — | IC50 | = | 1.35 | nM | 8.87 |
| CHEMBL5202965 | — | IC50 | = | 1.56 | nM | 8.81 |
| CHEMBL4595559 | — | IC50 | = | 4.95 | nM | 8.30 |
| CHEMBL5199098 | — | IC50 | = | 29.73 | nM | 7.53 |