Assay Detail
Functional
CHEMBL5159720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of CD86 expression in human MV4-11 cells incubated for 24 hrs by qRT-PCR analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.99 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786182 | GSK2879552 | 1.0 | 1 | 7.64 |
| CHEMBL5170011 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786182 | GSK2879552 | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5170011 | — | EC50 | = | 470.0 | nM | 6.33 |