Assay Detail
Functional
CHEMBL5159778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza B virus (B/Lee/1940) H1N1 infected in dog MDCK cells assessed as inhibition of viral cytopathic effect incubated for 48 hrs by CCK-8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza B virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Aryl Benzoyl Hydrazide Derivatives as Novel Potent Broad-Spectrum Inhibitors of Influenza A Virus RNA-Dependent RNA Polymerase (RdRp).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.87 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3779938 | — | — | 1 | 7.85 |
| CHEMBL5194584 | — | — | 1 | 7.70 |
| CHEMBL3781624 | — | — | 1 | 7.68 |
| CHEMBL3780361 | — | — | 1 | 7.57 |
| CHEMBL3781710 | — | — | 1 | 7.24 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.08 |
| CHEMBL3781695 | — | — | 1 | 5.72 |
| CHEMBL3781814 | — | — | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3779938 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5194584 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3781624 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3780361 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3781710 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3781695 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3781814 | — | EC50 | = | 72000.0 | nM | 4.14 |