Assay Detail
Functional
CHEMBL5159801
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Antiproliferative activity against human RPMI-8226 cells after 72 hrs by MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.64 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5204484 | — | — | 1 | 8.20 |
| CHEMBL4102324 | — | — | 1 | 7.99 |
| CHEMBL5197285 | — | — | 1 | 7.92 |
| CHEMBL5179570 | — | — | 1 | 7.82 |
| CHEMBL5208573 | — | — | 1 | 7.70 |
| CHEMBL5188065 | — | — | 1 | 7.68 |
| CHEMBL5202627 | — | — | 1 | 7.68 |
| CHEMBL5172645 | — | — | 1 | 7.62 |
| CHEMBL5201055 | — | — | 1 | 7.58 |
| CHEMBL5173459 | — | — | 1 | 7.47 |
| CHEMBL5171225 | — | — | 1 | 7.39 |
| CHEMBL5186240 | — | — | 1 | 7.22 |
| CHEMBL5209077 | — | — | 1 | 7.09 |
| CHEMBL5196378 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5204484 | — | IC50 | = | 6.347 | nM | 8.20 |
| CHEMBL4102324 | — | IC50 | = | 10.21 | nM | 7.99 |
| CHEMBL5197285 | — | IC50 | = | 12.08 | nM | 7.92 |
| CHEMBL5179570 | — | IC50 | = | 15.29 | nM | 7.82 |
| CHEMBL5208573 | — | IC50 | = | 19.94 | nM | 7.70 |
| CHEMBL5188065 | — | IC50 | = | 20.66 | nM | 7.68 |
| CHEMBL5202627 | — | IC50 | = | 20.81 | nM | 7.68 |
| CHEMBL5172645 | — | IC50 | = | 24.01 | nM | 7.62 |
| CHEMBL5201055 | — | IC50 | = | 26.18 | nM | 7.58 |
| CHEMBL5173459 | — | IC50 | = | 33.71 | nM | 7.47 |
| CHEMBL5171225 | — | IC50 | = | 40.73 | nM | 7.39 |
| CHEMBL5186240 | — | IC50 | = | 60.4 | nM | 7.22 |
| CHEMBL5209077 | — | IC50 | = | 81.69 | nM | 7.09 |
| CHEMBL5196378 | — | IC50 | > | 100.0 | nM | - |