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Assay Detail

CHEMBL5159803

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Functional
Antiproliferative activity against human MV4-11 cells after 72 hrs by MTS assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment.
Cao Y, Tu Y, Fu L, Yu Q, Gao L, Zhang M, Zeng L, Zhang C, Shao J, Zhu H, Zhou Y, Li J, Zhang J.
Eur J Med Chem (2022) 233 : 114211 -114211
PubMed 35218994 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 8.32 9.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5204484 1 9.01
CHEMBL5197285 1 8.80
CHEMBL5179570 1 8.61
CHEMBL5188065 1 8.56
CHEMBL5202627 1 8.39
CHEMBL5208573 1 8.34
CHEMBL5201055 1 8.31
CHEMBL5172645 1 8.31
CHEMBL5173459 1 8.31
CHEMBL5171225 1 8.17
CHEMBL5186240 1 8.12
CHEMBL5209077 1 7.92
CHEMBL5196378 1 7.29

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5204484 IC50 = 0.983 nM 9.01
CHEMBL5197285 IC50 = 1.571 nM 8.80
CHEMBL5179570 IC50 = 2.464 nM 8.61
CHEMBL5188065 IC50 = 2.74 nM 8.56
CHEMBL5202627 IC50 = 4.059 nM 8.39
CHEMBL5208573 IC50 = 4.602 nM 8.34
CHEMBL5201055 IC50 = 4.865 nM 8.31
CHEMBL5172645 IC50 = 4.927 nM 8.31
CHEMBL5173459 IC50 = 4.846 nM 8.31
CHEMBL5171225 IC50 = 6.831 nM 8.17
CHEMBL5186240 IC50 = 7.653 nM 8.12
CHEMBL5209077 IC50 = 12.0 nM 7.92
CHEMBL5196378 IC50 = 51.71 nM 7.29