Assay Detail
Functional
CHEMBL5159869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potentiation of cisplatin-induced cytotoxicity against human KBV cells assessed as cisplatin IC50 at 5 uM for 72 hrs by MTT assay (Rvb = 6.28 +/- 1.23 nM )
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KBV |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and tumor drug resistance reversal activity of novel hederagenin derivatives modified by nitrogen-containing heterocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.13 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 8.35 |
| CHEMBL5185253 | — | — | 1 | 8.34 |
| CHEMBL348475 | TARIQUIDAR | 3.0 | 1 | 8.02 |
| CHEMBL5181563 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | IC50 | = | 4.52 | nM | 8.35 |
| CHEMBL5185253 | — | IC50 | = | 4.54 | nM | 8.34 |
| CHEMBL348475 | TARIQUIDAR | IC50 | = | 9.51 | nM | 8.02 |
| CHEMBL5181563 | — | IC50 | = | 16.01 | nM | 7.80 |