Assay Detail
Toxicity
CHEMBL5160040
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Inhibition of hERG by Qpatch-clamp method
28
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.79 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5189523 | — | — | 1 | 5.62 |
| CHEMBL5190339 | — | — | 2 | 5.06 |
| CHEMBL5169763 | — | — | 2 | 5.04 |
| CHEMBL5200418 | — | — | 1 | 4.91 |
| CHEMBL5199435 | — | — | 1 | 4.75 |
| CHEMBL5178777 | — | — | 2 | 4.75 |
| CHEMBL5181112 | — | — | 1 | 4.73 |
| CHEMBL5198037 | — | — | 2 | 4.67 |
| CHEMBL5173722 | — | — | 1 | 4.67 |
| CHEMBL5179988 | — | — | 1 | 4.66 |
| CHEMBL5173264 | INE-963 | 2.0 | 1 | 4.64 |
| CHEMBL5174770 | — | — | 1 | 4.56 |
| CHEMBL5178067 | — | — | 2 | 4.55 |
| CHEMBL5197907 | — | — | 2 | 4.54 |
| CHEMBL5188137 | — | — | 1 | - |
| CHEMBL5187715 | — | — | 2 | - |
| CHEMBL5187946 | — | — | 2 | - |
| CHEMBL5174065 | — | — | 1 | - |
| CHEMBL5185965 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5189523 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5190339 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5169763 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL5200418 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL5190339 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL5169763 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL5199435 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL5178777 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL5181112 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL5173722 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL5198037 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL5179988 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5178777 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL5173264 | INE-963 | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5174770 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL5178067 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL5197907 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL5197907 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5187715 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5187715 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5178067 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5187946 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5188137 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5187946 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5198037 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5185965 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5174065 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5185965 | — | IC50 | > | 30000.0 | nM | - |