Assay Detail
Binding
CHEMBL5161216
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Inhibition of calcium channel (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.66 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170576 | — | — | 1 | 4.80 |
| CHEMBL5199698 | — | — | 1 | 4.73 |
| CHEMBL5184381 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170576 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5199698 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL5184381 | — | IC50 | = | 35300.0 | nM | 4.45 |