Assay Detail
Binding
CHEMBL5161260
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Inhibition of ROCK2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.15 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5202142 | — | — | 1 | 6.85 |
| CHEMBL5195653 | — | — | 1 | 6.11 |
| CHEMBL5185000 | — | — | 1 | 5.96 |
| CHEMBL5188433 | — | — | 1 | 5.96 |
| CHEMBL5184381 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5202142 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5195653 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5185000 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5188433 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5184381 | — | IC50 | = | 1300.0 | nM | 5.89 |