Assay Detail
Binding
CHEMBL5161322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGFR4 V550L mutant (unknown orgin) using poly(Glu, Tyr) 4:1 peptide as substrate incubated for 30 mins in presence of 50 uM ATP by ADP-Glo fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.29 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5194425 | — | — | 1 | 9.60 |
| CHEMBL5169893 | — | — | 1 | 8.89 |
| CHEMBL5198859 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5194425 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL5169893 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5198859 | — | IC50 | = | 407.0 | nM | 6.39 |