Assay Detail
Binding
CHEMBL5161345
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Inhibition of recombinant human sEH using CMNPC as substrate preincubated for 5 mins followed by substrate addition and measured every 30 sec for 10 mins for by fluorescence based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.72 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5204900 | — | — | 1 | 9.40 |
| CHEMBL5207628 | — | — | 1 | 9.40 |
| CHEMBL5200047 | — | — | 1 | 9.00 |
| CHEMBL5188116 | — | — | 1 | 8.51 |
| CHEMBL1668934 | — | — | 1 | 8.43 |
| CHEMBL5178885 | — | — | 1 | 8.34 |
| CHEMBL2007996 | — | — | 1 | 4.39 |
| CHEMBL292314 | — | — | 1 | 4.31 |
| CHEMBL2021616 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5204900 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5207628 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5200047 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5188116 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1668934 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5178885 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL2007996 | — | IC50 | = | 40996.0 | nM | 4.39 |
| CHEMBL292314 | — | IC50 | = | 49116.0 | nM | 4.31 |
| CHEMBL2021616 | — | IC50 | > | 50000.0 | nM | - |