Assay Detail
Binding
CHEMBL5161553
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Binding affinity to rabies recombinant GST-His-tagged G-glycoprotein protein (20 to 459 AA residues) expressed in Escherichia coli BL21 (DE3) cells assessed as Kd treated for 60 secs followed dissociation time of 120 secs by SPR analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lyssavirus rabies |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Clofazimine derivatives as potent broad-spectrum antiviral agents with dual-target mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 6.35 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1292 | CLOFAZIMINE | 4.0 | 1 | 6.55 |
| CHEMBL5183417 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1292 | CLOFAZIMINE | Kd | = | 280.0 | nM | 6.55 |
| CHEMBL5183417 | — | Kd | = | 730.0 | nM | 6.14 |