Assay Detail
Binding
CHEMBL5161876
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Binding affinity to recombinant Candida albicans Hsp90 NBD expressed in Escherichia coli by SPR assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.60 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414883 | RADICICOL | — | 1 | 8.70 |
| CHEMBL5205337 | — | — | 1 | 6.86 |
| CHEMBL252370 | — | — | 1 | 6.59 |
| CHEMBL5183986 | — | — | 1 | 6.32 |
| CHEMBL5204410 | — | — | 1 | 6.03 |
| CHEMBL254248 | — | — | 1 | 5.10 |
| CHEMBL5206875 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414883 | RADICICOL | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL5205337 | — | Kd | = | 139.0 | nM | 6.86 |
| CHEMBL252370 | — | Kd | = | 257.0 | nM | 6.59 |
| CHEMBL5183986 | — | Kd | = | 476.0 | nM | 6.32 |
| CHEMBL5204410 | — | Kd | = | 933.0 | nM | 6.03 |
| CHEMBL254248 | — | Kd | = | 7914.0 | nM | 5.10 |
| CHEMBL5206875 | — | Kd | > | 25000.0 | nM | - |