Assay Detail
Binding
CHEMBL5162430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of radiolabeled [3H]-2',3'-cGAMP from human STING HAQ variant incubated for 2 hrs by scintillation counting method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.76 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5197904 | — | — | 1 | 9.00 |
| CHEMBL5182772 | — | — | 1 | 8.96 |
| CHEMBL5175703 | — | — | 1 | 8.92 |
| CHEMBL5186267 | — | — | 1 | 8.89 |
| CHEMBL5191779 | — | — | 1 | 8.89 |
| CHEMBL5209233 | — | — | 1 | 8.89 |
| CHEMBL4465054 | — | — | 1 | 8.74 |
| CHEMBL5191008 | — | — | 1 | 8.62 |
| CHEMBL5205731 | — | — | 1 | 8.47 |
| CHEMBL5093161 | — | — | 1 | 8.22 |
| CHEMBL5174172 | — | — | 1 | - |
| CHEMBL5201164 | — | — | 1 | - |
| CHEMBL5185127 | — | — | 1 | - |
| CHEMBL5180220 | — | — | 1 | - |
| CHEMBL5188233 | — | — | 1 | - |
| CHEMBL5180005 | — | — | 1 | - |
| CHEMBL5174023 | — | — | 1 | - |
| CHEMBL5199659 | — | — | 1 | - |
| CHEMBL5183186 | — | — | 1 | - |
| CHEMBL5175739 | — | — | 1 | - |
| CHEMBL5181746 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5197904 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5182772 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5175703 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5186267 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5191779 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5209233 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4465054 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5191008 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5205731 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5093161 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5174172 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL5201164 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL5185127 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL5180220 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL5188233 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL5180005 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL5174023 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL5199659 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL5183186 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL5175739 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL5181746 | — | IC50 | < | 1.0 | nM | - |