Assay Detail
Binding
CHEMBL5162435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at STING HAQ variant in human THP1 cell assessed as increase in human INF-beta production incubated for 5 hrs by mesoscale assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 5.77 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5188233 | — | — | 1 | 6.16 |
| CHEMBL5197904 | — | — | 1 | 6.09 |
| CHEMBL5180220 | — | — | 1 | 6.05 |
| CHEMBL5185127 | — | — | 1 | 6.00 |
| CHEMBL5175739 | — | — | 1 | 5.99 |
| CHEMBL5180005 | — | — | 1 | 5.95 |
| CHEMBL5174023 | — | — | 1 | 5.90 |
| CHEMBL5205731 | — | — | 1 | 5.87 |
| CHEMBL5093161 | — | — | 1 | 5.86 |
| CHEMBL5174172 | — | — | 1 | 5.82 |
| CHEMBL5181746 | — | — | 1 | 5.80 |
| CHEMBL5201164 | — | — | 1 | 5.77 |
| CHEMBL5209233 | — | — | 1 | 5.76 |
| CHEMBL5199659 | — | — | 1 | 5.72 |
| CHEMBL5182772 | — | — | 1 | 5.67 |
| CHEMBL5175703 | — | — | 1 | 5.65 |
| CHEMBL5191008 | — | — | 1 | 5.64 |
| CHEMBL5191779 | — | — | 1 | 5.46 |
| CHEMBL5186267 | — | — | 1 | 5.43 |
| CHEMBL5183186 | — | — | 1 | 5.37 |
| CHEMBL4465054 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5188233 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5197904 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5180220 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5185127 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5175739 | — | EC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL5180005 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5174023 | — | EC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL5205731 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5093161 | — | EC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL5174172 | — | EC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL5181746 | — | EC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL5201164 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5209233 | — | EC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL5199659 | — | EC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL5182772 | — | EC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL5175703 | — | EC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL5191008 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5191779 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5186267 | — | EC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL5183186 | — | EC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL4465054 | — | EC50 | = | 4960.0 | nM | 5.30 |