Assay Detail

CHEMBL5162436

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Binding

Binding affinity to wild type human STING assessed as dissociation constant by Surface plasmon resonance assay

ChEMBL ↗

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Target

Stimulator of interferon genes protein (CHEMBL4523377) ↗

Open DB target context

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Stimulator of interferon genes protein (CHEMBL4523377) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Stimulator of interferon genes protein

CHEMBL4523377

Anchored from Assay target.

Protein identity Stimulator of interferon genes protein

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Stimulator of interferon genes protein (CHEMBL4523377) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.

Chang W, Altman MD, Lesburg CA, Perera SA, Piesvaux JA, Schroeder GK, Wyss DF, Cemerski S, Chen Y, DiNunzio E, Haidle AM, Ho T, Kariv I, Knemeyer I, Kopinja JE, Lacey BM, Laskey J, Lim J, Long BJ, Ma Y, Maddess ML, Pan BS, Presland JP, Spooner E, Steinhuebel D, Truong Q, Zhang Z, Fu J, Addona GH, Northrup AB, Parmee E, Tata JR, Bennett DJ, Cumming JN, Siu T, Trotter BW.
J Med Chem (2022) 65 : 5675 -5689
PubMed 35332774 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	8.37	8.53

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5188233	—	—	1	8.53
CHEMBL4465054	—	—	1	8.21

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5188233	—	Kd	=	2.95	nM	8.53
CHEMBL4465054	—	Kd	=	6.2	nM	8.21