Assay Detail
Binding
CHEMBL5162464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at STING HAQ variant in mouse BMDC cells assessed as increase in mouse INF-beta production incubated for 5 hrs by ELISA
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BMDC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523311) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 4.93 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5188233 | — | — | 1 | 6.09 |
| CHEMBL5185127 | — | — | 1 | 5.81 |
| CHEMBL5197904 | — | — | 1 | 5.49 |
| CHEMBL5093161 | — | — | 1 | 5.37 |
| CHEMBL5201164 | — | — | 1 | 5.27 |
| CHEMBL5180005 | — | — | 1 | 5.21 |
| CHEMBL5199659 | — | — | 1 | 5.03 |
| CHEMBL5181746 | — | — | 1 | 4.97 |
| CHEMBL5174172 | — | — | 1 | 4.82 |
| CHEMBL5186267 | — | — | 1 | 4.80 |
| CHEMBL5205731 | — | — | 1 | 4.71 |
| CHEMBL5209233 | — | — | 1 | 4.63 |
| CHEMBL5175703 | — | — | 1 | 4.63 |
| CHEMBL4465054 | — | — | 1 | 4.62 |
| CHEMBL5174023 | — | — | 1 | 4.57 |
| CHEMBL5182772 | — | — | 1 | 4.51 |
| CHEMBL5180220 | — | — | 1 | 4.42 |
| CHEMBL5175739 | — | — | 1 | 4.37 |
| CHEMBL5191779 | — | — | 1 | 4.36 |
| CHEMBL5183186 | — | — | 1 | - |
| CHEMBL5191008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5188233 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL5185127 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL5197904 | — | EC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL5093161 | — | EC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL5201164 | — | EC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL5180005 | — | EC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL5199659 | — | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5181746 | — | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL5174172 | — | EC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL5186267 | — | EC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL5205731 | — | EC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL5209233 | — | EC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL5175703 | — | EC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL4465054 | — | EC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL5174023 | — | EC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL5182772 | — | EC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL5180220 | — | EC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL5175739 | — | EC50 | = | 42700.0 | nM | 4.37 |
| CHEMBL5191779 | — | EC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL5183186 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5191008 | — | EC50 | > | 100000.0 | nM | - |