Assay Detail
Binding
CHEMBL5162563
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to His6-fused human BRD3 BD1 assessed as dissociation constant in PBS incubated for 1 hrs by biolayer interferometry analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Discovery and Optimization of Furo[3,2-<i>c</i>]pyridin-4(5<i>H</i>)-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 5.45 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206088 | — | — | 1 | 5.88 |
| CHEMBL5204783 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206088 | — | Kd | = | 1328.0 | nM | 5.88 |
| CHEMBL5204783 | — | Kd | = | 9780.0 | nM | 5.01 |