Assay Detail
Functional
CHEMBL5162580
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Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on O-alkylamino-tethered salicylamide derivatives with various amino acid linkers as potent anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.41 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5176855 | — | — | 1 | 5.75 |
| CHEMBL5209175 | — | — | 1 | 5.62 |
| CHEMBL5192197 | — | — | 1 | 5.58 |
| CHEMBL5207308 | — | — | 1 | 5.45 |
| CHEMBL2326743 | — | — | 1 | 5.30 |
| CHEMBL5185574 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5176855 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5209175 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL5192197 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL5207308 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL2326743 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL5185574 | — | IC50 | = | 18280.0 | nM | 4.74 |