Assay Detail
Functional
CHEMBL5162610
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Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of oxoisoaporphine derivatives with topoisomerase I inhibition and reversal of multidrug resistance in breast cancer MCF-7/ADR cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.09 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.38 |
| CHEMBL5173600 | — | — | 1 | 5.62 |
| CHEMBL5174899 | — | — | 1 | 5.14 |
| CHEMBL5201001 | — | — | 1 | 5.13 |
| CHEMBL5175089 | — | — | 1 | 5.13 |
| CHEMBL5180889 | — | — | 1 | 5.10 |
| CHEMBL5173403 | — | — | 1 | 5.08 |
| CHEMBL5197764 | — | — | 1 | 5.08 |
| CHEMBL5181693 | — | — | 1 | 5.07 |
| CHEMBL5176760 | — | — | 1 | 5.07 |
| CHEMBL5193242 | — | — | 1 | 5.07 |
| CHEMBL1770207 | — | — | 1 | 5.03 |
| CHEMBL5191277 | — | — | 1 | 5.03 |
| CHEMBL5191037 | — | — | 1 | 5.02 |
| CHEMBL5202016 | — | — | 1 | 5.02 |
| CHEMBL5187198 | — | — | 1 | 5.00 |
| CHEMBL5199620 | — | — | 1 | 4.99 |
| CHEMBL1770208 | — | — | 1 | 4.98 |
| CHEMBL5176659 | — | — | 1 | 4.96 |
| CHEMBL5170317 | — | — | 1 | 4.94 |
| CHEMBL5200627 | — | — | 1 | 4.92 |
| CHEMBL5183351 | — | — | 1 | 4.92 |
| CHEMBL461133 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5173600 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL5174899 | — | IC50 | = | 7180.0 | nM | 5.14 |
| CHEMBL5201001 | — | IC50 | = | 7390.0 | nM | 5.13 |
| CHEMBL5175089 | — | IC50 | = | 7340.0 | nM | 5.13 |
| CHEMBL5180889 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL5173403 | — | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL5197764 | — | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL5181693 | — | IC50 | = | 8480.0 | nM | 5.07 |
| CHEMBL5176760 | — | IC50 | = | 8460.0 | nM | 5.07 |
| CHEMBL5193242 | — | IC50 | = | 8610.0 | nM | 5.07 |
| CHEMBL1770207 | — | IC50 | = | 9330.0 | nM | 5.03 |
| CHEMBL5191277 | — | IC50 | = | 9430.0 | nM | 5.03 |
| CHEMBL5191037 | — | IC50 | = | 9470.0 | nM | 5.02 |
| CHEMBL5202016 | — | IC50 | = | 9520.0 | nM | 5.02 |
| CHEMBL5187198 | — | IC50 | = | 10030.0 | nM | 5.00 |
| CHEMBL5199620 | — | IC50 | = | 10210.0 | nM | 4.99 |
| CHEMBL1770208 | — | IC50 | = | 10490.0 | nM | 4.98 |
| CHEMBL5176659 | — | IC50 | = | 11080.0 | nM | 4.96 |
| CHEMBL5170317 | — | IC50 | = | 11390.0 | nM | 4.94 |
| CHEMBL5200627 | — | IC50 | = | 12060.0 | nM | 4.92 |
| CHEMBL5183351 | — | IC50 | = | 12010.0 | nM | 4.92 |
| CHEMBL461133 | — | IC50 | = | 32180.0 | nM | 4.49 |