Assay Detail
Functional
CHEMBL5162910
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Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition measured upto 4 hrs by CellTiter-Blue cell viability assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.65 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522892 | DOVITINIB | 3.0 | 1 | 6.58 |
| CHEMBL5205434 | — | — | 1 | 6.39 |
| CHEMBL5169362 | — | — | 1 | 6.30 |
| CHEMBL5173972 | — | — | 1 | 6.23 |
| CHEMBL5183674 | — | — | 1 | 6.23 |
| CHEMBL5189185 | — | — | 1 | 6.19 |
| CHEMBL5190625 | — | — | 1 | 6.15 |
| CHEMBL5173261 | — | — | 1 | 6.13 |
| CHEMBL5184524 | — | — | 1 | 6.03 |
| CHEMBL5206333 | — | — | 1 | 6.00 |
| CHEMBL5198100 | — | — | 1 | 5.96 |
| CHEMBL5185748 | — | — | 1 | 5.74 |
| CHEMBL5188083 | — | — | 1 | 5.73 |
| CHEMBL5199887 | — | — | 1 | 5.71 |
| CHEMBL5209513 | — | — | 1 | 5.70 |
| CHEMBL5177051 | — | — | 1 | 5.61 |
| CHEMBL5205101 | — | — | 1 | 5.11 |
| CHEMBL5176979 | — | — | 1 | 5.03 |
| CHEMBL5207705 | — | — | 1 | 4.94 |
| CHEMBL5207842 | — | — | 1 | 4.85 |
| CHEMBL5207335 | — | — | 1 | 4.74 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 4.30 |
| CHEMBL5177337 | — | — | 1 | 4.20 |
| CHEMBL5173318 | — | — | 1 | - |
| CHEMBL5202676 | — | — | 1 | - |
| CHEMBL210833 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522892 | DOVITINIB | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL5205434 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL5169362 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL5173972 | — | IC50 | = | 586.0 | nM | 6.23 |
| CHEMBL5183674 | — | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL5189185 | — | IC50 | = | 644.0 | nM | 6.19 |
| CHEMBL5190625 | — | IC50 | = | 711.0 | nM | 6.15 |
| CHEMBL5173261 | — | IC50 | = | 743.0 | nM | 6.13 |
| CHEMBL5184524 | — | IC50 | = | 943.0 | nM | 6.03 |
| CHEMBL5206333 | — | IC50 | = | 1008.0 | nM | 6.00 |
| CHEMBL5198100 | — | IC50 | = | 1088.0 | nM | 5.96 |
| CHEMBL5185748 | — | IC50 | = | 1842.0 | nM | 5.74 |
| CHEMBL5188083 | — | IC50 | = | 1877.0 | nM | 5.73 |
| CHEMBL5199887 | — | IC50 | = | 1927.0 | nM | 5.71 |
| CHEMBL5209513 | — | IC50 | = | 1983.0 | nM | 5.70 |
| CHEMBL5177051 | — | IC50 | = | 2433.0 | nM | 5.61 |
| CHEMBL5205101 | — | IC50 | = | 7799.0 | nM | 5.11 |
| CHEMBL5176979 | — | IC50 | = | 9356.0 | nM | 5.03 |
| CHEMBL5207705 | — | IC50 | = | 11571.0 | nM | 4.94 |
| CHEMBL5207842 | — | IC50 | = | 14120.0 | nM | 4.85 |
| CHEMBL5207335 | — | IC50 | = | 18141.0 | nM | 4.74 |
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 50281.0 | nM | 4.30 |
| CHEMBL5177337 | — | IC50 | = | 62750.0 | nM | 4.20 |
| CHEMBL5173318 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5202676 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL210833 | — | IC50 | > | 100000.0 | nM | - |