Assay Detail
Functional
CHEMBL5162914
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Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition measured upto 4 hrs by CellTiter-Blue cell viability assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.23 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 8.52 |
| CHEMBL522892 | DOVITINIB | 3.0 | 1 | 8.40 |
| CHEMBL5183674 | — | — | 1 | 7.96 |
| CHEMBL5206333 | — | — | 1 | 7.46 |
| CHEMBL5176979 | — | — | 1 | 7.00 |
| CHEMBL5173972 | — | — | 1 | 6.96 |
| CHEMBL5189185 | — | — | 1 | 6.94 |
| CHEMBL5209513 | — | — | 1 | 6.80 |
| CHEMBL5184524 | — | — | 1 | 6.54 |
| CHEMBL210833 | — | — | 1 | 6.49 |
| CHEMBL5190625 | — | — | 1 | 6.45 |
| CHEMBL5185748 | — | — | 1 | 6.42 |
| CHEMBL5198100 | — | — | 1 | 6.41 |
| CHEMBL5188083 | — | — | 1 | 6.33 |
| CHEMBL5169362 | — | — | 1 | 5.94 |
| CHEMBL5205434 | — | — | 1 | 5.68 |
| CHEMBL5199887 | — | — | 1 | 5.65 |
| CHEMBL5207842 | — | — | 1 | 5.53 |
| CHEMBL5177051 | — | — | 1 | 5.35 |
| CHEMBL5207705 | — | — | 1 | 5.11 |
| CHEMBL5207335 | — | — | 1 | 5.07 |
| CHEMBL5205101 | — | — | 1 | 5.06 |
| CHEMBL5173318 | — | — | 1 | 4.83 |
| CHEMBL5177337 | — | — | 1 | 4.57 |
| CHEMBL5173261 | — | — | 1 | 4.31 |
| CHEMBL5202676 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL522892 | DOVITINIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5183674 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5206333 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5176979 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL5173972 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL5189185 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL5209513 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL5184524 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL210833 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL5190625 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL5185748 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL5198100 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL5188083 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL5169362 | — | IC50 | = | 1152.0 | nM | 5.94 |
| CHEMBL5205434 | — | IC50 | = | 2108.0 | nM | 5.68 |
| CHEMBL5199887 | — | IC50 | = | 2249.0 | nM | 5.65 |
| CHEMBL5207842 | — | IC50 | = | 2959.0 | nM | 5.53 |
| CHEMBL5177051 | — | IC50 | = | 4431.0 | nM | 5.35 |
| CHEMBL5207705 | — | IC50 | = | 7775.0 | nM | 5.11 |
| CHEMBL5207335 | — | IC50 | = | 8522.0 | nM | 5.07 |
| CHEMBL5205101 | — | IC50 | = | 8714.0 | nM | 5.06 |
| CHEMBL5173318 | — | IC50 | = | 14901.0 | nM | 4.83 |
| CHEMBL5177337 | — | IC50 | = | 26880.0 | nM | 4.57 |
| CHEMBL5173261 | — | IC50 | = | 48660.0 | nM | 4.31 |
| CHEMBL5202676 | — | IC50 | > | 100000.0 | nM | - |