Assay Detail
Functional
CHEMBL5162920
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Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured upto 4 hrs by CellTiter-Blue cell viability assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.12 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5173972 | — | — | 1 | 5.88 |
| CHEMBL5185748 | — | — | 1 | 5.86 |
| CHEMBL5183674 | — | — | 1 | 5.80 |
| CHEMBL5189185 | — | — | 1 | 5.79 |
| CHEMBL522892 | DOVITINIB | 3.0 | 1 | 5.70 |
| CHEMBL5190625 | — | — | 1 | 5.49 |
| CHEMBL5184524 | — | — | 1 | 5.48 |
| CHEMBL5198100 | — | — | 1 | 5.41 |
| CHEMBL5206333 | — | — | 1 | 5.38 |
| CHEMBL5177051 | — | — | 1 | 5.38 |
| CHEMBL5205434 | — | — | 1 | 5.27 |
| CHEMBL5169362 | — | — | 1 | 5.19 |
| CHEMBL5207842 | — | — | 1 | 4.96 |
| CHEMBL5205101 | — | — | 1 | 4.93 |
| CHEMBL5207705 | — | — | 1 | 4.90 |
| CHEMBL5209513 | — | — | 1 | 4.88 |
| CHEMBL5176979 | — | — | 1 | 4.86 |
| CHEMBL5207335 | — | — | 1 | 4.77 |
| CHEMBL5173318 | — | — | 1 | 4.77 |
| CHEMBL5199887 | — | — | 1 | 4.71 |
| CHEMBL5173261 | — | — | 1 | 4.30 |
| CHEMBL5177337 | — | — | 1 | 4.15 |
| CHEMBL5188083 | — | — | 1 | 4.00 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | - |
| CHEMBL5202676 | — | — | 1 | - |
| CHEMBL210833 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5173972 | — | IC50 | = | 1309.0 | nM | 5.88 |
| CHEMBL5185748 | — | IC50 | = | 1373.0 | nM | 5.86 |
| CHEMBL5183674 | — | IC50 | = | 1582.0 | nM | 5.80 |
| CHEMBL5189185 | — | IC50 | = | 1633.0 | nM | 5.79 |
| CHEMBL522892 | DOVITINIB | IC50 | = | 2018.0 | nM | 5.70 |
| CHEMBL5190625 | — | IC50 | = | 3237.0 | nM | 5.49 |
| CHEMBL5184524 | — | IC50 | = | 3332.0 | nM | 5.48 |
| CHEMBL5198100 | — | IC50 | = | 3866.0 | nM | 5.41 |
| CHEMBL5206333 | — | IC50 | = | 4151.0 | nM | 5.38 |
| CHEMBL5177051 | — | IC50 | = | 4168.0 | nM | 5.38 |
| CHEMBL5205434 | — | IC50 | = | 5328.0 | nM | 5.27 |
| CHEMBL5169362 | — | IC50 | = | 6416.0 | nM | 5.19 |
| CHEMBL5207842 | — | IC50 | = | 11010.0 | nM | 4.96 |
| CHEMBL5205101 | — | IC50 | = | 11850.0 | nM | 4.93 |
| CHEMBL5207705 | — | IC50 | = | 12521.0 | nM | 4.90 |
| CHEMBL5209513 | — | IC50 | = | 13201.0 | nM | 4.88 |
| CHEMBL5176979 | — | IC50 | = | 13860.0 | nM | 4.86 |
| CHEMBL5207335 | — | IC50 | = | 16970.0 | nM | 4.77 |
| CHEMBL5173318 | — | IC50 | = | 17141.0 | nM | 4.77 |
| CHEMBL5199887 | — | IC50 | = | 19330.0 | nM | 4.71 |
| CHEMBL5173261 | — | IC50 | = | 50631.0 | nM | 4.30 |
| CHEMBL5177337 | — | IC50 | = | 70400.0 | nM | 4.15 |
| CHEMBL5188083 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL576982 | QUIZARTINIB | IC50 | > | 100000.0 | nM | - |
| CHEMBL5202676 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL210833 | — | IC50 | > | 100000.0 | nM | - |