Assay Detail

CHEMBL5163364

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against SARS-CoV-2 delta TY11-927-P1 infected in Vero E6 cells expressing human transmembrane protease serine 2 assessed as inhibition of virus induced cytopathic effect by measuring cell viability by celltiter-Glo 2.0 assay

ChEMBL ↗

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Target

SARS-CoV-2 (CHEMBL4303835) ↗

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SARS-CoV-2 (CHEMBL4303835) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target SARS-CoV-2

CHEMBL4303835

Anchored from Assay target.

Protein identity SARS-CoV-2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Severe acute respiratory syndrome coronavirus 2
Cell Type	Vero E6
Confidence	1 — Organism
Curated By	Autocuration

Target

SARS-CoV-2 (CHEMBL4303835) ↗

Type	ORGANISM
Organism	Severe acute respiratory syndrome coronavirus 2

Publication

Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19.

Unoh Y, Uehara S, Nakahara K, Nobori H, Yamatsu Y, Yamamoto S, Maruyama Y, Taoda Y, Kasamatsu K, Suto T, Kouki K, Nakahashi A, Kawashima S, Sanaki T, Toba S, Uemura K, Mizutare T, Ando S, Sasaki M, Orba Y, Sawa H, Sato A, Sato T, Kato T, Tachibana Y.
J Med Chem (2022) 65 : 6499 -6512
PubMed 35352927 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.39	6.39

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5183847	ENSITRELVIR	3.0	1	6.39

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5183847	ENSITRELVIR	EC50	=	410.0	nM	6.39