Assay Detail
Functional
CHEMBL5163406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 6 days by cell titre glo luminescence assay
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Thieno[2,3-<i>e</i>]indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 60 | 8.34 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5171948 | — | — | 1 | 9.30 |
| CHEMBL5177756 | — | — | 1 | 9.22 |
| CHEMBL5173113 | — | — | 1 | 9.22 |
| CHEMBL5205357 | — | — | 1 | 9.22 |
| CHEMBL5205039 | — | — | 1 | 9.15 |
| CHEMBL5180046 | — | — | 1 | 9.10 |
| CHEMBL5169445 | — | — | 1 | 9.10 |
| CHEMBL5184413 | — | — | 1 | 9.10 |
| CHEMBL5181850 | — | — | 1 | 9.05 |
| CHEMBL5185539 | — | — | 1 | 9.00 |
| CHEMBL5190953 | — | — | 1 | 9.00 |
| CHEMBL5207484 | — | — | 1 | 8.96 |
| CHEMBL5197035 | — | — | 1 | 8.96 |
| CHEMBL5203346 | — | — | 1 | 8.92 |
| CHEMBL5207893 | — | — | 1 | 8.92 |
| CHEMBL5191700 | — | — | 1 | 8.85 |
| CHEMBL5171955 | — | — | 1 | 8.85 |
| CHEMBL5189071 | — | — | 1 | 8.82 |
| CHEMBL5181826 | — | — | 1 | 8.80 |
| CHEMBL5191391 | — | — | 1 | 8.77 |
| CHEMBL5198894 | — | — | 1 | 8.77 |
| CHEMBL5208566 | — | — | 1 | 8.77 |
| CHEMBL5202286 | — | — | 1 | 8.72 |
| CHEMBL5198039 | — | — | 1 | 8.66 |
| CHEMBL5193428 | — | — | 1 | 8.62 |
| CHEMBL5174315 | — | — | 1 | 8.59 |
| CHEMBL5187985 | — | — | 1 | 8.57 |
| CHEMBL5205546 | — | — | 1 | 8.55 |
| CHEMBL5184683 | — | — | 1 | 8.48 |
| CHEMBL5191161 | — | — | 1 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5171948 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5177756 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5205357 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5173113 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5205039 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5180046 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5169445 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5184413 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5181850 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5185539 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5190953 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5207484 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5197035 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5207893 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5203346 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5191700 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5171955 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5189071 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5181826 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5191391 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5198894 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5208566 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5202286 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5198039 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5193428 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5174315 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5187985 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5205546 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5184683 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5191161 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5173602 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5206306 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL5188343 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5170271 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5208192 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL5198988 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5207013 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5202599 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5172442 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5198626 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL5200219 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5179839 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL5192103 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4475463 | AMCENESTRANT | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL5208191 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL5178254 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL5181707 | — | IC50 | = | 19.4 | nM | 7.71 |
| CHEMBL5187550 | — | IC50 | = | 23.9 | nM | 7.62 |
| CHEMBL5178968 | — | IC50 | = | 26.6 | nM | 7.58 |
| CHEMBL5176820 | — | IC50 | = | 27.3 | nM | 7.56 |