Assay Detail
Functional
CHEMBL5163435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF-7/TAMR-1 cells assessed as inhibition of cell growth measured after 8 days by cell titre glo luminescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF-7/TAMR-1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Thieno[2,3-<i>e</i>]indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.39 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5185539 | — | — | 1 | 8.49 |
| CHEMBL5197035 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5185539 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5197035 | — | IC50 | = | 5.2 | nM | 8.28 |