Assay Detail
Binding
CHEMBL5163693
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Inhibition of human cytomegalovirus pHAR-UL89C expressed in Escherichia coli Rosette using Digoxigenin-labeled 5'-taatcgccttgcagcacatccccattcgccagctggcgtaatagcgaagaggcccgca ssDNA as substrate preincubated for 15 mins followed by substrate addition for 30 mins by plate reader assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cytomegalovirus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tripartite terminase subunit 3 (CHEMBL4879551) ↗| Type | SINGLE PROTEIN |
| Organism | Human cytomegalovirus |
Publication
4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.84 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5185038 | — | — | 1 | 6.27 |
| CHEMBL5205946 | — | — | 1 | 6.23 |
| CHEMBL204900 | — | — | 1 | 6.21 |
| CHEMBL551212 | — | — | 1 | 6.17 |
| CHEMBL216874 | — | — | 1 | 6.16 |
| CHEMBL1085364 | — | — | 1 | 6.13 |
| CHEMBL5203198 | — | — | 1 | 6.12 |
| CHEMBL5203310 | — | — | 1 | 6.11 |
| CHEMBL5190900 | — | — | 1 | 6.10 |
| CHEMBL5171144 | — | — | 1 | 6.07 |
| CHEMBL5196576 | — | — | 1 | 6.06 |
| CHEMBL187010 | — | — | 1 | 6.06 |
| CHEMBL5184216 | — | — | 1 | 6.04 |
| CHEMBL5172238 | — | — | 1 | 6.00 |
| CHEMBL3617204 | — | — | 1 | 5.96 |
| CHEMBL181653 | — | — | 1 | 5.92 |
| CHEMBL4228948 | — | — | 1 | 5.92 |
| CHEMBL232444 | — | — | 1 | 5.89 |
| CHEMBL5208893 | — | — | 1 | 5.89 |
| CHEMBL5209461 | — | — | 1 | 5.85 |
| CHEMBL379015 | — | — | 1 | 5.85 |
| CHEMBL437708 | — | — | 1 | 5.85 |
| CHEMBL5188107 | — | — | 1 | 5.82 |
| CHEMBL5201304 | — | — | 1 | 5.77 |
| CHEMBL5208229 | — | — | 1 | 5.75 |
| CHEMBL277754 | — | — | 1 | 5.72 |
| CHEMBL5182790 | — | — | 1 | 5.68 |
| CHEMBL4174171 | — | — | 1 | 5.68 |
| CHEMBL5177803 | — | — | 1 | 5.62 |
| CHEMBL1077377 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5185038 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5205946 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL204900 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL551212 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL216874 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1085364 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5203198 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5203310 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5190900 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5171144 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5196576 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL187010 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5184216 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5172238 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3617204 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL181653 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4228948 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL232444 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5208893 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5209461 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL437708 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL379015 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5188107 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5201304 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5208229 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL277754 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5182790 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4174171 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5177803 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1077377 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5187369 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5199493 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5185724 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5200751 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4863466 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL440562 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5194424 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5184235 | — | IC50 | = | 5700.0 | nM | 5.24 |