Assay Detail
Functional
CHEMBL5163695
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Antiviral activity against human cytomegalovirus expressing ADCREGFP infected in HFF cells assessed as inhibition in viral replication by measuring GFP fluorescence incubated for 168 hrs by cell based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cytomegalovirus |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.03 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 6.00 |
| CHEMBL4848335 | — | — | 1 | 5.54 |
| CHEMBL4863466 | — | — | 1 | 5.31 |
| CHEMBL4475877 | — | — | 1 | 5.10 |
| CHEMBL5199493 | — | — | 1 | 4.84 |
| CHEMBL5182790 | — | — | 1 | 4.76 |
| CHEMBL181653 | — | — | 1 | 4.74 |
| CHEMBL551212 | — | — | 1 | 4.70 |
| CHEMBL187010 | — | — | 1 | 4.68 |
| CHEMBL5203310 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4848335 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4863466 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4475877 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5199493 | — | EC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL5182790 | — | EC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL181653 | — | EC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL551212 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL187010 | — | EC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL5203310 | — | EC50 | = | 22800.0 | nM | 4.64 |