Assay Detail
Functional
CHEMBL5163785
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Growth inhibition of human U-937 cells incubated for 4 days by WST assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.09 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5177177 | — | — | 1 | 5.55 |
| CHEMBL5188901 | — | — | 1 | 5.03 |
| CHEMBL4576854 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5177177 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5188901 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4576854 | — | IC50 | = | 19900.0 | nM | 4.70 |