Assay Detail
Functional
CHEMBL5164018
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Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by CCK8 assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.38 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5169455 | — | — | 1 | 8.10 |
| CHEMBL4303781 | — | — | 1 | 7.99 |
| CHEMBL5181042 | — | — | 1 | 7.99 |
| CHEMBL5172487 | — | — | 1 | 7.97 |
| CHEMBL5209531 | — | — | 1 | 7.92 |
| CHEMBL5203560 | — | — | 1 | 7.73 |
| CHEMBL5206001 | — | — | 1 | 7.61 |
| CHEMBL5175586 | — | — | 1 | 7.61 |
| CHEMBL5185340 | — | — | 1 | 7.57 |
| CHEMBL5189384 | — | — | 1 | 7.52 |
| CHEMBL5203520 | — | — | 1 | 7.48 |
| CHEMBL5193742 | — | — | 1 | 7.36 |
| CHEMBL5188851 | — | — | 1 | 7.34 |
| CHEMBL5175450 | — | — | 1 | 7.07 |
| CHEMBL4297454 | ABBV-744 | 1.0 | 1 | 6.82 |
| CHEMBL5200802 | — | — | 1 | 6.06 |
| CHEMBL5186542 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5169455 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4303781 | — | IC50 | = | 10.33 | nM | 7.99 |
| CHEMBL5181042 | — | IC50 | = | 10.33 | nM | 7.99 |
| CHEMBL5172487 | — | IC50 | = | 10.67 | nM | 7.97 |
| CHEMBL5209531 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5203560 | — | IC50 | = | 18.67 | nM | 7.73 |
| CHEMBL5206001 | — | IC50 | = | 24.33 | nM | 7.61 |
| CHEMBL5175586 | — | IC50 | = | 24.67 | nM | 7.61 |
| CHEMBL5185340 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5189384 | — | IC50 | = | 30.33 | nM | 7.52 |
| CHEMBL5203520 | — | IC50 | = | 33.33 | nM | 7.48 |
| CHEMBL5193742 | — | IC50 | = | 43.67 | nM | 7.36 |
| CHEMBL5188851 | — | IC50 | = | 45.67 | nM | 7.34 |
| CHEMBL5175450 | — | IC50 | = | 84.33 | nM | 7.07 |
| CHEMBL4297454 | ABBV-744 | IC50 | = | 152.67 | nM | 6.82 |
| CHEMBL5200802 | — | IC50 | = | 863.33 | nM | 6.06 |
| CHEMBL5186542 | — | IC50 | = | 4127.33 | nM | 5.38 |