Assay Detail
Binding
CHEMBL5164481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at AhR (unknown origin) transfected in human AZ-AHR reporter cells derived from human HepG2 cells incubated for 4 hrs by luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | AZ-AHR |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting the Aryl Hydrocarbon Receptor with Microbial Metabolite Mimics Alleviates Experimental Colitis in Mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 8 | - | - |
| EC50 | 3 | 7.75 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5198290 | — | — | 1 | 8.80 |
| CHEMBL5185943 | — | — | 1 | 7.50 |
| CHEMBL5179114 | — | — | 1 | 6.96 |
| CHEMBL5187691 | — | — | 1 | - |
| CHEMBL5188811 | — | — | 1 | - |
| CHEMBL5186558 | — | — | 1 | - |
| CHEMBL3259980 | — | — | 1 | - |
| CHEMBL5171196 | — | — | 1 | - |
| CHEMBL5184653 | — | — | 1 | - |
| CHEMBL5205137 | — | — | 1 | - |
| CHEMBL5171454 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5198290 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5185943 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5179114 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5187691 | — | Activity | - | — | - | |
| CHEMBL5188811 | — | Activity | - | — | - | |
| CHEMBL5186558 | — | Activity | - | — | - | |
| CHEMBL3259980 | — | Activity | - | — | - | |
| CHEMBL5171196 | — | Activity | - | — | - | |
| CHEMBL5184653 | — | Activity | - | — | - | |
| CHEMBL5205137 | — | Activity | - | — | - | |
| CHEMBL5171454 | — | Activity | - | — | - |