Assay Detail
Binding
CHEMBL5164641
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Inhibition of MDM4 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.24 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206050 | — | — | 1 | 6.24 |
| CHEMBL2402573 | — | — | 1 | 6.24 |
| CHEMBL3125702 | NAVTEMADLIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206050 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL2402573 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3125702 | NAVTEMADLIN | IC50 | > | 10000.0 | nM | - |