Assay Detail
Binding
CHEMBL5164643
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Inhibition of human MDM4 by TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.32 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5180980 | — | — | 1 | 7.77 |
| CHEMBL3601398 | CGM-097 | 1.0 | 1 | 5.66 |
| CHEMBL3653256 | SIREMADLIN | 2.0 | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5180980 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3601398 | CGM-097 | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3653256 | SIREMADLIN | IC50 | = | 3000.0 | nM | 5.52 |