Assay Detail
Functional
CHEMBL5164657
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Cytotoxicity against human U2OS cells expressing wild type p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.09 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5181559 | — | — | 1 | 6.43 |
| CHEMBL5205792 | — | — | 1 | 6.30 |
| CHEMBL5196857 | — | — | 1 | 6.19 |
| CHEMBL5176086 | — | — | 1 | 6.09 |
| CHEMBL5188708 | — | — | 1 | 6.07 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5181559 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5205792 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5196857 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5176086 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5188708 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 3350.0 | nM | 5.47 |