Assay Detail
Functional
CHEMBL5164796
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Antiproliferative activity against human KM12-Luc cells assessed as inhibition of cell growth incubated for 3 days by CCK8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KM12-Luc |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.23 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | 8.64 |
| CHEMBL5195469 | — | — | 1 | 7.81 |
| CHEMBL3889654 | LAROTRECTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297627 | SELITRECTINIB | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5195469 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL3889654 | LAROTRECTINIB | IC50 | - | — | - |