Assay Detail
Functional
CHEMBL5165094
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Reactivation of mouse CTLL-2 cells pretreated with human PD-L1 assessed as increase in cell proliferation and measured by flow cytometry assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CTLL-2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.52 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207924 | — | — | 1 | 8.39 |
| CHEMBL5176505 | — | — | 1 | 7.85 |
| CHEMBL5194957 | — | — | 1 | 7.27 |
| CHEMBL5171729 | — | — | 1 | 7.12 |
| CHEMBL374252 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207924 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5176505 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5194957 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5171729 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL374252 | — | IC50 | = | 102.0 | nM | 6.99 |