Assay Detail
Binding
CHEMBL5165149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of biotinylated human RAGE/amyloid beta interaction incubated for 120 mins by ELISA assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Advanced glycosylation end product-specific receptor (CHEMBL2176846) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.07 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5191418 | — | — | 1 | 5.46 |
| CHEMBL5194592 | — | — | 1 | 5.39 |
| CHEMBL5170867 | — | — | 1 | 5.38 |
| CHEMBL5180815 | — | — | 1 | 5.22 |
| CHEMBL5175011 | — | — | 1 | 5.08 |
| CHEMBL5203206 | — | — | 1 | 5.08 |
| CHEMBL2179073 | — | — | 1 | 4.98 |
| CHEMBL5208902 | — | — | 1 | 4.90 |
| CHEMBL5188606 | — | — | 1 | 4.89 |
| CHEMBL3989929 | AZELIRAGON | 3.0 | 1 | 4.87 |
| CHEMBL5192104 | — | — | 1 | 4.85 |
| CHEMBL5170035 | — | — | 1 | 4.79 |
| CHEMBL5206806 | — | — | 1 | - |
| CHEMBL5208411 | — | — | 1 | - |
| CHEMBL5196372 | — | — | 1 | - |
| CHEMBL5172417 | — | — | 1 | - |
| CHEMBL5174761 | — | — | 1 | - |
| CHEMBL5204858 | — | — | 1 | - |
| CHEMBL5178447 | — | — | 1 | - |
| CHEMBL5199141 | — | — | 1 | - |
| CHEMBL5181226 | — | — | 1 | - |
| CHEMBL5176363 | — | — | 1 | - |
| CHEMBL5184959 | — | — | 1 | - |
| CHEMBL5178292 | — | — | 1 | - |
| CHEMBL5170676 | — | — | 1 | - |
| CHEMBL5183581 | — | — | 1 | - |
| CHEMBL5204395 | — | — | 1 | - |
| CHEMBL5172714 | — | — | 1 | - |
| CHEMBL5173093 | — | — | 1 | - |
| CHEMBL5200156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5191418 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL5194592 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL5170867 | — | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL5180815 | — | IC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL5175011 | — | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL5203206 | — | IC50 | = | 8260.0 | nM | 5.08 |
| CHEMBL2179073 | — | IC50 | = | 10530.0 | nM | 4.98 |
| CHEMBL5208902 | — | IC50 | = | 12490.0 | nM | 4.90 |
| CHEMBL5188606 | — | IC50 | = | 12920.0 | nM | 4.89 |
| CHEMBL3989929 | AZELIRAGON | IC50 | = | 13470.0 | nM | 4.87 |
| CHEMBL5192104 | — | IC50 | = | 14270.0 | nM | 4.85 |
| CHEMBL5170035 | — | IC50 | = | 16050.0 | nM | 4.79 |
| CHEMBL5174761 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5172417 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5196372 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5208411 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5206806 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5177452 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5183093 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5201565 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5180472 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5170075 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5207117 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL439849 | VILAZODONE | IC50 | > | 200000.0 | nM | - |
| CHEMBL5204858 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5178447 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5199141 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5181226 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5176363 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5184959 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5178292 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5170676 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5183581 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5204395 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5172714 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5173093 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5200156 | — | IC50 | > | 20000.0 | nM | - |