Assay Detail
Toxicity
CHEMBL5165162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG transfected in CHO cells by manual patch-clamp assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.20 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 5.25 |
| CHEMBL5203206 | — | — | 1 | 5.14 |
| CHEMBL3989929 | AZELIRAGON | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5203206 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3989929 | AZELIRAGON | IC50 | < | 1000.0 | nM | - |