Assay Detail
Binding
CHEMBL5165664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MKK3-p38-elF4E signaling pathway in mouse RAW264.7 cells assessed as inhibition of LPS-induced MKK3 phosphorylation
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of First-in-Class TAK1-MKK3 Protein-Protein Interaction (PPI) Inhibitor <b>(<i>R</i>)-STU104</b> for the Treatment of Ulcerative Colitis through Modulating TNF-α Production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.40 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178905 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178905 | — | IC50 | = | 4000.0 | nM | 5.40 |