Assay Detail
Binding
CHEMBL5165829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SHP2 (unknown origin) using DiFMUP as substrate incubated for 60 mins followed by substrate addition for 30 mins by microplate reader method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Novel Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) and Cyclin-Dependent Kinase 4 (CDK4) Dual Inhibitor for the Treatment of Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.46 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5171286 | — | — | 1 | 8.49 |
| CHEMBL4650521 | BATOPROTAFIB | 2.0 | 1 | 8.42 |
| CHEMBL5179617 | — | — | 1 | 8.37 |
| CHEMBL5194505 | — | — | 1 | 8.09 |
| CHEMBL5200081 | — | — | 1 | 7.78 |
| CHEMBL5204959 | — | — | 1 | 7.50 |
| CHEMBL5199829 | — | — | 1 | 7.47 |
| CHEMBL5195043 | — | — | 1 | 7.33 |
| CHEMBL5180571 | — | — | 1 | 7.28 |
| CHEMBL5200166 | — | — | 1 | 7.22 |
| CHEMBL5176602 | — | — | 1 | 6.69 |
| CHEMBL5172609 | — | — | 1 | 6.21 |
| CHEMBL5184331 | — | — | 1 | 6.17 |
| CHEMBL5178361 | — | — | 1 | - |
| CHEMBL5179046 | — | — | 1 | - |
| CHEMBL5184558 | — | — | 1 | - |
| CHEMBL5196278 | — | — | 1 | - |
| CHEMBL5177262 | — | — | 1 | - |
| CHEMBL5205964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5171286 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4650521 | BATOPROTAFIB | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5179617 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL5194505 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL5200081 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL5204959 | — | IC50 | = | 31.3 | nM | 7.50 |
| CHEMBL5199829 | — | IC50 | = | 34.1 | nM | 7.47 |
| CHEMBL5195043 | — | IC50 | = | 47.2 | nM | 7.33 |
| CHEMBL5180571 | — | IC50 | = | 52.1 | nM | 7.28 |
| CHEMBL5200166 | — | IC50 | = | 60.6 | nM | 7.22 |
| CHEMBL5176602 | — | IC50 | = | 205.1 | nM | 6.69 |
| CHEMBL5172609 | — | IC50 | = | 618.3 | nM | 6.21 |
| CHEMBL5184331 | — | IC50 | = | 673.0 | nM | 6.17 |
| CHEMBL5178361 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5179046 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5184558 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5196278 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5177262 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5205964 | — | IC50 | > | 1000.0 | nM | - |