Assay Detail
Functional
CHEMBL5165832
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Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Novel Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) and Cyclin-Dependent Kinase 4 (CDK4) Dual Inhibitor for the Treatment of Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.24 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5179617 | — | — | 1 | 5.75 |
| CHEMBL5194505 | — | — | 1 | 5.41 |
| CHEMBL5200081 | — | — | 1 | 5.04 |
| CHEMBL5195043 | — | — | 1 | 5.02 |
| CHEMBL5200166 | — | — | 1 | 4.99 |
| CHEMBL4650521 | BATOPROTAFIB | 2.0 | 1 | - |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5179617 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL5194505 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5200081 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5195043 | — | IC50 | = | 9620.0 | nM | 5.02 |
| CHEMBL5200166 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4650521 | BATOPROTAFIB | IC50 | > | 20000.0 | nM | - |
| CHEMBL3301610 | ABEMACICLIB | IC50 | > | 20000.0 | nM | - |