Assay Detail
Functional
CHEMBL5165834
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse EMT6 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | EMT6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Novel Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) and Cyclin-Dependent Kinase 4 (CDK4) Dual Inhibitor for the Treatment of Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.81 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5200081 | — | — | 1 | 6.24 |
| CHEMBL5179617 | — | — | 1 | 6.19 |
| CHEMBL5194505 | — | — | 1 | 5.97 |
| CHEMBL5195043 | — | — | 1 | 5.96 |
| CHEMBL5200166 | — | — | 1 | 5.78 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 5.38 |
| CHEMBL4650521 | BATOPROTAFIB | 2.0 | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5200081 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5179617 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5194505 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL5195043 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5200166 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL4650521 | BATOPROTAFIB | IC50 | = | 7030.0 | nM | 5.15 |