Assay Detail
Functional
CHEMBL5165835
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Antiproliferative activity against mouse EMT6 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of abemaciclib by MTT assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | EMT6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Novel Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) and Cyclin-Dependent Kinase 4 (CDK4) Dual Inhibitor for the Treatment of Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.60 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4650521 | BATOPROTAFIB | 2.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4650521 | BATOPROTAFIB | IC50 | = | 2490.0 | nM | 5.60 |