Assay Detail
Binding
CHEMBL5165906
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant mouse CLK1 expressed in bacteria using GRSRSRSRSRSR as substrate in presence of ATP measured after 30 mins by ADP-Glo assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK1 (CHEMBL1075280) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.14 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178368 | — | — | 1 | 8.10 |
| CHEMBL5186093 | — | — | 1 | 7.70 |
| CHEMBL5188318 | — | — | 1 | 7.43 |
| CHEMBL5177344 | — | — | 1 | 7.14 |
| CHEMBL5194011 | — | — | 1 | 7.05 |
| CHEMBL5186471 | — | — | 1 | 7.04 |
| CHEMBL5196946 | — | — | 1 | 6.83 |
| CHEMBL5183366 | — | — | 1 | 6.66 |
| CHEMBL5181620 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178368 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5186093 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5188318 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5177344 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5194011 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5186471 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5196946 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL5183366 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL5181620 | — | IC50 | = | 445.0 | nM | 6.35 |