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Assay Detail

CHEMBL5165914

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant CK1 epsilon expressed in baculovirus in sf9 insect cells using RRKHAAIGSpAYSITA as substrate in presence of ATP measured after 30 mins by ADP-Glo assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf9
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Casein kinase I isoform epsilon (CHEMBL4937)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity.
Zeinyeh W, Esvan YJ, Josselin B, Defois M, Baratte B, Knapp S, Chaikuad A, Anizon F, Giraud F, Ruchaud S, Moreau P.
Eur J Med Chem (2022) 236 : 114369 -114369
PubMed 35447555 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.00 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5178368 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5178368 IC50 = 99.0 nM 7.00