Assay Detail
Binding
CHEMBL5166044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal 6His-MBP-tagged recombinant human IP6K1 expressed in Escherichia coli assessed as inorganic phosphate release using InsP6 as substrate in presence of ATP measured after 60 to 120 mins by malachite green based colorimetric - DIPP1 coupled enzyme assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inositol hexakisphosphate kinase 1 (CHEMBL4523418) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.31 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5169462 | — | — | 1 | 7.58 |
| CHEMBL5181623 | — | — | 1 | 7.57 |
| CHEMBL5190343 | — | — | 1 | 7.24 |
| CHEMBL5200214 | — | — | 1 | 7.11 |
| CHEMBL5184940 | — | — | 1 | 7.09 |
| CHEMBL5204881 | — | — | 1 | 7.08 |
| CHEMBL5186210 | — | — | 1 | 6.96 |
| CHEMBL5201056 | — | — | 1 | 6.89 |
| CHEMBL5184960 | — | — | 1 | 6.89 |
| CHEMBL5190846 | — | — | 1 | 6.80 |
| CHEMBL5196483 | — | — | 1 | 6.77 |
| CHEMBL5201078 | — | — | 1 | 6.77 |
| CHEMBL5197626 | — | — | 1 | 6.72 |
| CHEMBL5175579 | — | — | 1 | 6.62 |
| CHEMBL5186729 | — | — | 1 | 6.55 |
| CHEMBL5188320 | — | — | 1 | 6.50 |
| CHEMBL5198845 | — | — | 1 | 6.43 |
| CHEMBL5192487 | — | — | 1 | 6.37 |
| CHEMBL5206215 | — | — | 1 | 6.37 |
| CHEMBL5185725 | — | — | 1 | 6.35 |
| CHEMBL5203362 | — | — | 1 | 6.21 |
| CHEMBL5189856 | — | — | 1 | 6.16 |
| CHEMBL5171388 | — | — | 1 | 6.15 |
| CHEMBL5185229 | — | — | 1 | 6.10 |
| CHEMBL1485263 | — | — | 1 | 6.07 |
| CHEMBL1460920 | — | — | 1 | 6.04 |
| CHEMBL467591 | — | — | 1 | 6.00 |
| CHEMBL1379963 | — | — | 1 | 5.95 |
| CHEMBL5205377 | — | — | 1 | 5.81 |
| CHEMBL5199101 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5169462 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5181623 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5190343 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5200214 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5184940 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL5204881 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL5186210 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5201056 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5184960 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5190846 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5196483 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5201078 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5197626 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5175579 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5186729 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5188320 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5198845 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5206215 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5192487 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5185725 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5203362 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5189856 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5171388 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5185229 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1485263 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL1460920 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL467591 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1379963 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5205377 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL5199101 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL5178548 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1368139 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5209246 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL5195827 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL5178065 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL5188989 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5177760 | — | IC50 | = | 29500.0 | nM | 4.53 |