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Assay Detail

CHEMBL5166069

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 18 hrs by HPLC analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions.
Zhou Y, Mukherjee S, Huang D, Chakraborty M, Gu C, Zong G, Stashko MA, Pearce KH, Shears SB, Chakraborty A, Wang H, Wang X.
J Med Chem (2022) 65 : 6869 -6887
PubMed 35467861 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 6.62 6.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5190343 1 6.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5190343 EC50 = 240.0 nM 6.62