Assay Detail
Functional
CHEMBL5166204
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Antiproliferative activity against human HOS cells assessed as inhibition of cell growth incubated for 48 hrs by cell titer based MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HOS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.43 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5182175 | — | — | 1 | 6.96 |
| CHEMBL5174100 | — | — | 1 | 6.77 |
| CHEMBL5175326 | — | — | 1 | 6.75 |
| CHEMBL5178793 | — | — | 1 | 6.66 |
| CHEMBL5204232 | — | — | 1 | 6.22 |
| CHEMBL1829876 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5182175 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5174100 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5175326 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5178793 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5204232 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1829876 | — | IC50 | = | 6440.0 | nM | 5.19 |