Assay Detail
Functional
CHEMBL5166205
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Antiproliferative activity against human MG-63 cells assessed as inhibition of cell growth incubated for 48 hrs by cell titer based MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MG-63 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.28 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178793 | — | — | 1 | 6.92 |
| CHEMBL5174100 | — | — | 1 | 6.82 |
| CHEMBL5175326 | — | — | 1 | 6.52 |
| CHEMBL5204232 | — | — | 1 | 6.27 |
| CHEMBL5182175 | — | — | 1 | 6.26 |
| CHEMBL1829876 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178793 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5174100 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5175326 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5204232 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5182175 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1829876 | — | IC50 | = | 12660.0 | nM | 4.90 |